DAN RUO IVF CLINIC
PGT refers to genetic testing of embryos. Different types address different questions, so the exact test and reason for testing matter.
What is PGT-A?
PGT-A assesses chromosome number in embryo cells. It does not test for every genetic condition. It has not been shown to improve the chance of a baby for most IVF patients, although it may reduce miscarriage risk in some circumstances. It is not a routine requirement for everyone having IVF, and a discussion should distinguish outcomes per transfer from the chance of a baby across an entire cycle.
What is PGT-M?
PGT-M looks for a specific inherited single-gene condition. A known genetic finding, such as a familial thalassaemia variant, may prompt a genetics consultation. The laboratory must assess whether a suitable test can be developed for the family.
What is PGT-SR?
PGT-SR is used when a parent has a structural chromosome rearrangement, such as a balanced translocation. It looks for unbalanced chromosome material in embryos. Ask whether the proposed method distinguishes a carrier embryo from one without the rearrangement.
How does the testing journey work?
Begin with a review of genetic reports and family history. If testing is appropriate, clarify the laboratory requirements before starting IVF. Embryo sampling, testing and the later transfer decision are separate steps; confirm the expected timing and costs with your team.
What do the results mean?
Results need interpretation in context. Ask how the laboratory reports uncertain or mosaic findings, and what options exist if no embryo is considered suitable for transfer. Testing cannot guarantee pregnancy or a child without health problems.
What should we discuss before deciding?
Ask about test accuracy, the possibility of an inconclusive result, embryo biopsy risks and alternatives. Discuss whether prenatal testing would still be advised after pregnancy. Genetic counselling can help connect the result to your family’s choices.